Genotype-guided tacrolimus dosing in African American kidney transplant recipients

Tacrolimus is dependent on CYP3A5 enzyme for metabolism. Expression of the CYP3A5 enzyme is controlled by several alleles including CYP3A5*1, CYP3A5*3, CYP3A5*6 and CYP3A5*7. African Americans (AA) have on average higher tacrolimus dose requirements than Caucasians; however, some have requirements s...

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Bibliografski detalji
Izdano u:Pharmacogenomics J
Glavni autori: Sanghavi, K., Brundage, RC., Miller, MB., Schladt, DP., Israni, AK., Guan, W., Oettin, WS., Mannon, RB., Remme, RP., Matas, AJ., Jacobson, PA.
Format: Artigo
Jezik:Inglês
Izdano: 2015
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4909584/
https://ncbi.nlm.nih.gov/pubmed/26667830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tpj.2015.87
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