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Dabigatran and Argatroban Diametrically Modulate Thrombin Exosite Function
Thrombin is a highly plastic molecule whose activity and specificity are regulated by exosites 1 and 2, positively-charged domains that flank the active site. Exosite binding by substrates and cofactors regulates thrombin activity by localizing thrombin, guiding substrates, and by inducing allosteri...
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| Publicat a: | PLoS One |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4909201/ https://ncbi.nlm.nih.gov/pubmed/27305147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0157471 |
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