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Dabigatran and Argatroban Diametrically Modulate Thrombin Exosite Function
Thrombin is a highly plastic molecule whose activity and specificity are regulated by exosites 1 and 2, positively-charged domains that flank the active site. Exosite binding by substrates and cofactors regulates thrombin activity by localizing thrombin, guiding substrates, and by inducing allosteri...
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| Pubblicato in: | PLoS One |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4909201/ https://ncbi.nlm.nih.gov/pubmed/27305147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0157471 |
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