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Lysosomal cystine accumulation promotes mitochondrial depolarization and induction of redox‐sensitive genes in human kidney proximal tubular cells
KEY POINTS: Cystine is a disulphide amino acid that is normally generated in the lysosomes by the breakdown of cystine‐containing proteins. Previously, we demonstrated that lysosomal cystine accumulation in kidney proximal tubular epithelial cells (PTECs) dramatically reduced glutathione (GSH) level...
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| Publicado no: | J Physiol |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4908017/ https://ncbi.nlm.nih.gov/pubmed/26915455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP271858 |
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