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HIV-1 Tat Protein Activates both the MyD88 and TRIF Pathways To Induce Tumor Necrosis Factor Alpha and Interleukin-10 in Human Monocytes

In this study, we show that the HIV-1 Tat protein interacts with rapid kinetics to engage the Toll-like receptor 4 (TLR4) pathway, leading to the production of proinflammatory and anti-inflammatory cytokines. The pretreatment of human monocytes with Tat protein for 10 to 30 min suffices to irreversi...

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Bibliografske podrobnosti
izdano v:J Virol
Main Authors: Planès, Rémi, Ben Haij, Nawal, Leghmari, Kaoutar, Serrero, Manutea, BenMohamed, Lbachir, Bahraoui, Elmostafa
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4907244/
https://ncbi.nlm.nih.gov/pubmed/27053552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00262-16
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