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HIV-1 Tat – TLR4/MD2 interaction drives the expression of IDO-1 in monocytes derived dendritic cells through NF-κB dependent pathway

In the present study we showed that HIV-1 Tat protein stimulated the expression of Indoleamine 2,3 dioxygenase (IDO) -1 in human monocytes derived dendritic cells (MoDC) but not IDO-2 by acting directly at the cell membrane level. This induction of IDO-1 is dependent on the secondary structure of Ta...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Bahraoui, Elmostafa, Serrero, Manutea, Planès, Rémi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7235218/
https://ncbi.nlm.nih.gov/pubmed/32424165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-64847-y
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