HIV-1 Tat Protein Induces Production of Proinflammatory Cytokines by Human Dendritic Cells and Monocytes/Macrophages through Engagement of TLR4-MD2-CD14 Complex and Activation of NF-κB Pathway

We recently reported that the human immunodeficiency virus type-1 (HIV-1) Tat protein induced the expression of programmed death ligand-1 (PD-L1) on dendritic cells (DCs) through a TLR4 pathway. However, the underlying mechanisms by which HIV-1 Tat protein induces the abnormal hyper-activation of th...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ben Haij, Nawal, Planès, Rémi, Leghmari, Kaoutar, Serrero, Manutea, Delobel, Pierre, Izopet, Jacques, BenMohamed, Lbachir, Bahraoui, Elmostafa
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4474861/
https://ncbi.nlm.nih.gov/pubmed/26090662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129425
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