HIV-1 Tat protein binds to TLR4-MD2 and signals to induce TNF-α and IL-10

BACKGROUND: HIV-1 infection results in hyper-immune activation and immunological disorders as early as the asymptomatic stage. Here, we hypothesized that during early HIV-1 infection, HIV-1 Tat protein acts on monocytes/macrophages to induce anti-inflammatory and proinflammatory cytokines and partic...

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Bibliographische Detailangaben
Veröffentlicht in:Retrovirology
Hauptverfasser: Ben Haij, Nawal, Leghmari, Kaoutar, Planès, Rémi, Thieblemont, Nathalie, Bahraoui, Elmostafa
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231456/
https://ncbi.nlm.nih.gov/pubmed/24165011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-10-123
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