Chaperonin TRiC/CCT Recognizes Fusion Oncoprotein AML1-ETO through Subunit-Specific Interactions

AML1-ETO is the translational product of a chimeric gene created by the stable chromosome translocation t (8;21)(q22;q22). It causes acute myeloid leukemia (AML) by dysregulating the expression of genes critical for myeloid cell development and differentiation and recently has been reported to bind...

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Bibliografische gegevens
Gepubliceerd in:Biophys J
Hoofdauteurs: Roh, Soung-Hun, Kasembeli, Moses M., Galaz-Montoya, Jesús G., Chiu, Wah, Tweardy, David J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Biophysical Society 2016
Onderwerpen:
Proteins
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4906440/
https://ncbi.nlm.nih.gov/pubmed/27276256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.04.045
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