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RAS-MAPK signaling influences the efficacy of ALK-targeting agents in lung cancer
ALK (anaplastic lymphoma kinase) inhibitors are approved in for ALK gene rearrangement positive (ALK+) lung cancer, but resistance remains a challenge. We discovered that RAS-RAF-MEK-ERK signaling controls the ALK inhibitor response in ALK+ lung cancer and is critical for ALK inhibitor resistance. U...
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| Izdano u: | Mol Cell Oncol |
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| Glavni autori: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Taylor & Francis
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4905399/ https://ncbi.nlm.nih.gov/pubmed/27308613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2015.1091061 |
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