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A cancerous web: signaling, metabolism, and the epigenome

Histone acetylation is sensitive to the availability of acetyl-CoA. However, the extent to which metabolic alterations in cancer cells impact tumor histone acetylation has been unclear. Here, we discuss our recent findings that oncogenic AKT1 activation regulates histone acetylation levels in tumors...

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Publicado en:Mol Cell Oncol
Main Authors: Lee, Joyce V., Shah, Supriya, Carrer, Alessandro, Wellen, Kathryn E.
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4904988/
https://ncbi.nlm.nih.gov/pubmed/27308412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/23723548.2014.965620
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