Large-scale epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis

During the evolutionary progression of pancreatic ductal adenocarcinoma (PDAC), heterogeneous subclonal populations emerge that drive primary tumor growth, regional spread, distant metastasis, and patient death(1–3). However, the genetics of metastases largely reflects that of the primary tumor in u...

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Bibliografski detalji
Izdano u:Nat Genet
Glavni autori: McDonald, Oliver G., Li, Xin, Saunders, Tyler, Tryggvadottir, Rakel, Mentch, Samantha J., Warmoes, Marc O., Word, Anna E., Carrer, Alessandro, Salz, Tal H., Natsume, Sonoko, Stauffer, Kimberly M., Makohon-Moore, Alvin, Zhong, Yi, Wu, Hao, Wellen, Kathryn E., Locasale, Jason W., Iacobuzio-Donahue, Christine, Feinberg, Andrew P.
Format: Artigo
Jezik:Inglês
Izdano: 2017
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5695682/
https://ncbi.nlm.nih.gov/pubmed/28092686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3753
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