Large-scale epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis

During the evolutionary progression of pancreatic ductal adenocarcinoma (PDAC), heterogeneous subclonal populations emerge that drive primary tumor growth, regional spread, distant metastasis, and patient death(1–3). However, the genetics of metastases largely reflects that of the primary tumor in u...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: McDonald, Oliver G., Li, Xin, Saunders, Tyler, Tryggvadottir, Rakel, Mentch, Samantha J., Warmoes, Marc O., Word, Anna E., Carrer, Alessandro, Salz, Tal H., Natsume, Sonoko, Stauffer, Kimberly M., Makohon-Moore, Alvin, Zhong, Yi, Wu, Hao, Wellen, Kathryn E., Locasale, Jason W., Iacobuzio-Donahue, Christine, Feinberg, Andrew P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5695682/
https://ncbi.nlm.nih.gov/pubmed/28092686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3753
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