Large-scale epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis

During the evolutionary progression of pancreatic ductal adenocarcinoma (PDAC), heterogeneous subclonal populations emerge that drive primary tumor growth, regional spread, distant metastasis, and patient death(1–3). However, the genetics of metastases largely reflects that of the primary tumor in u...

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Vydáno v:Nat Genet
Hlavní autoři: McDonald, Oliver G., Li, Xin, Saunders, Tyler, Tryggvadottir, Rakel, Mentch, Samantha J., Warmoes, Marc O., Word, Anna E., Carrer, Alessandro, Salz, Tal H., Natsume, Sonoko, Stauffer, Kimberly M., Makohon-Moore, Alvin, Zhong, Yi, Wu, Hao, Wellen, Kathryn E., Locasale, Jason W., Iacobuzio-Donahue, Christine, Feinberg, Andrew P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5695682/
https://ncbi.nlm.nih.gov/pubmed/28092686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3753
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