Large-scale epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis

During the evolutionary progression of pancreatic ductal adenocarcinoma (PDAC), heterogeneous subclonal populations emerge that drive primary tumor growth, regional spread, distant metastasis, and patient death(1–3). However, the genetics of metastases largely reflects that of the primary tumor in u...

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Dades bibliogràfiques
Publicat a:Nat Genet
Autors principals: McDonald, Oliver G., Li, Xin, Saunders, Tyler, Tryggvadottir, Rakel, Mentch, Samantha J., Warmoes, Marc O., Word, Anna E., Carrer, Alessandro, Salz, Tal H., Natsume, Sonoko, Stauffer, Kimberly M., Makohon-Moore, Alvin, Zhong, Yi, Wu, Hao, Wellen, Kathryn E., Locasale, Jason W., Iacobuzio-Donahue, Christine, Feinberg, Andrew P.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5695682/
https://ncbi.nlm.nih.gov/pubmed/28092686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3753
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