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A cancerous web: signaling, metabolism, and the epigenome

Histone acetylation is sensitive to the availability of acetyl-CoA. However, the extent to which metabolic alterations in cancer cells impact tumor histone acetylation has been unclear. Here, we discuss our recent findings that oncogenic AKT1 activation regulates histone acetylation levels in tumors...

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Bibliografiske detaljer
Udgivet i:Mol Cell Oncol
Main Authors: Lee, Joyce V., Shah, Supriya, Carrer, Alessandro, Wellen, Kathryn E.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4904988/
https://ncbi.nlm.nih.gov/pubmed/27308412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/23723548.2014.965620
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