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Single-Molecule Decoding of Combinatorially-Modified Nucleosomes
Different combinations of histone modifications have been proposed to signal distinct gene regulatory functions, but are poorly addressed by existing technologies. Here, we apply high-throughput single-molecule imaging to decode combinatorial modifications on millions of individual nucleosomes from...
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| Published in: | Science |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4904710/ https://ncbi.nlm.nih.gov/pubmed/27151869 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad7701 |
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