Nucleosomal arrangement affects single-molecule transcription dynamics

In eukaryotes, gene expression depends on chromatin organization. However, how chromatin affects the transcription dynamics of individual RNA polymerases has remained elusive. Here, we use dual trap optical tweezers to study single yeast RNA polymerase II (Pol II) molecules transcribing along a DNA...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Fitz, Veronika, Shin, Jaeoh, Ehrlich, Christoph, Farnung, Lucas, Cramer, Patrick, Zaburdaev, Vasily, Grill, Stephan W.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111697/
https://ncbi.nlm.nih.gov/pubmed/27791062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1602764113
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