Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor

The spiroindolones, a new class of antimalarial medicines discovered in a cellular screen, are rendered less active by mutations in a parasite P-type ATPase, PfATP4. We show here that S. cerevisiae also acquires mutations in a gene encoding a P-type ATPase (ScPMA1) after exposure to spiroindolones a...

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Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Goldgof, Gregory M., Durrant, Jacob D., Ottilie, Sabine, Vigil, Edgar, Allen, Kenneth E., Gunawan, Felicia, Kostylev, Maxim, Henderson, Kiersten A., Yang, Jennifer, Schenken, Jake, LaMonte, Gregory M., Manary, Micah J., Murao, Ayako, Nachon, Marie, Murray, Rebecca, Prescott, Maximo, McNamara, Case W., Slayman, Carolyn W., Amaro, Rommie E., Suzuki, Yo, Winzeler, Elizabeth A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2016
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4904242/
https://ncbi.nlm.nih.gov/pubmed/27291296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27806
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