Pyruvate Kinase Isoform Switching and Hepatic Metabolic Reprogramming by the Environmental Contaminant 2,3,7,8-Tetrachlorodibenzo-p-Dioxin

The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) elicits dose-dependent hepatotoxicity that includes fat accumulation, inflammation, and fibrosis that may progress to hepatocellular carcinoma. To further investigate these effects, RNA-Seq data were integrated with computation...

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Veröffentlicht in:Toxicol Sci
Hauptverfasser: Nault, Rance, Fader, Kelly A., Kirby, Mathew P., Ahmed, Shaimaa, Matthews, Jason, Jones, A. Daniel, Lunt, Sophia Y., Zacharewski, Timothy R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
Schlagworte:
TCDD Causes Metabolic Reprogramming in Liver
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4900217/
https://ncbi.nlm.nih.gov/pubmed/26582802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv245
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