Validating novel tau PET tracer [F-18]-AV-1451 (T807) on postmortem brain tissue

OBJECTIVE: To examine region and substrate-specific autoradiographic and in vitro binding patterns of PET tracer [F-18]-AV-1451 (previously known as T807), tailored to allow in vivo detection of paired helical filament tau-containing lesions, and to determine whether there is off-target binding to o...

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Udgivet i:Ann Neurol
Main Authors: Marquie, Marta, Normandin, Marc D., Vanderburg, Charles R., Costantino, Isabel, Bien, Elizabeth A., Rycyna, Lisa G., Klunk, William E., Mathis, Chester A., Ikonomovic, Milos D., Debnath, Manik L., Vasdev, Neil, Dickerson, Bradford C., Gomperts, Stephen N., Growdon, John H., Johnson, Keith A., Frosch, Matthew P., Hyman, Bradley T., Gomez-Isla, Teresa
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4900162/
https://ncbi.nlm.nih.gov/pubmed/26344059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24517
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