Validating novel tau PET tracer [F-18]-AV-1451 (T807) on postmortem brain tissue

OBJECTIVE: To examine region and substrate-specific autoradiographic and in vitro binding patterns of PET tracer [F-18]-AV-1451 (previously known as T807), tailored to allow in vivo detection of paired helical filament tau-containing lesions, and to determine whether there is off-target binding to o...

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Publicado no:Ann Neurol
Main Authors: Marquie, Marta, Normandin, Marc D., Vanderburg, Charles R., Costantino, Isabel, Bien, Elizabeth A., Rycyna, Lisa G., Klunk, William E., Mathis, Chester A., Ikonomovic, Milos D., Debnath, Manik L., Vasdev, Neil, Dickerson, Bradford C., Gomperts, Stephen N., Growdon, John H., Johnson, Keith A., Frosch, Matthew P., Hyman, Bradley T., Gomez-Isla, Teresa
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4900162/
https://ncbi.nlm.nih.gov/pubmed/26344059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24517
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