Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity

Many hereditary and sporadic neurodegenerative disorders are characterized by the accumulation of aberrant proteins. In sporadic Parkinson's disease, representing the most prevalent movement disorder, oxidative and nitrosative stress are believed to contribute to disease pathogenesis, but the e...

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Main Authors: Yao, Dongdong, Gu, Zezong, Nakamura, Tomohiro, Shi, Zhong-Qing, Ma, Yuliang, Gaston, Benjamin, Palmer, Lisa A., Rockenstein, Edward M., Zhang, Zhuohua, Masliah, Eliezer, Uehara, Takashi, Lipton, Stuart A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2004
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC490016/
https://ncbi.nlm.nih.gov/pubmed/15252205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404161101
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