S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson’s disease

BACKGROUND: Mutations in the gene encoding parkin, a neuroprotective protein with dual functions as an E3 ubiquitin ligase and transcriptional repressor of p53, are linked to familial forms of Parkinson’s disease (PD). We hypothesized that oxidative posttranslational modification of parkin by enviro...

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Hlavní autoři: Sunico, Carmen R, Nakamura, Tomohiro, Rockenstein, Edward, Mante, Michael, Adame, Anthony, Chan, Shing Fai, Newmeyer, Traci Fang, Masliah, Eliezer, Nakanishi, Nobuki, Lipton, Stuart A
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3765907/
https://ncbi.nlm.nih.gov/pubmed/23985028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-8-29
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