S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson’s disease

BACKGROUND: Mutations in the gene encoding parkin, a neuroprotective protein with dual functions as an E3 ubiquitin ligase and transcriptional repressor of p53, are linked to familial forms of Parkinson’s disease (PD). We hypothesized that oxidative posttranslational modification of parkin by enviro...

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Main Authors: Sunico, Carmen R, Nakamura, Tomohiro, Rockenstein, Edward, Mante, Michael, Adame, Anthony, Chan, Shing Fai, Newmeyer, Traci Fang, Masliah, Eliezer, Nakanishi, Nobuki, Lipton, Stuart A
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3765907/
https://ncbi.nlm.nih.gov/pubmed/23985028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-8-29
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