S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson’s disease

BACKGROUND: Mutations in the gene encoding parkin, a neuroprotective protein with dual functions as an E3 ubiquitin ligase and transcriptional repressor of p53, are linked to familial forms of Parkinson’s disease (PD). We hypothesized that oxidative posttranslational modification of parkin by enviro...

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Autori principali: Sunico, Carmen R, Nakamura, Tomohiro, Rockenstein, Edward, Mante, Michael, Adame, Anthony, Chan, Shing Fai, Newmeyer, Traci Fang, Masliah, Eliezer, Nakanishi, Nobuki, Lipton, Stuart A
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3765907/
https://ncbi.nlm.nih.gov/pubmed/23985028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-8-29
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