Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation

BACKGROUND: Accumulation of aberrant proteins to form Lewy bodies (LBs) is a hallmark of Parkinson's disease (PD). Ubiquitination-mediated degradation of aberrant, misfolded proteins is critical for maintaining normal cell function. Emerging evidence suggests that oxidative/nitrosative stress c...

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Bibliographische Detailangaben
Hauptverfasser: Meng, Fanjun, Yao, Dongdong, Shi, Yang, Kabakoff, Jonathan, Wu, Wei, Reicher, Joshua, Ma, Yuliang, Moosmann, Bernd, Masliah, Eliezer, Lipton, Stuart A, Gu, Zezong
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3120712/
https://ncbi.nlm.nih.gov/pubmed/21595948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-6-34
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