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Pruning and loss of excitatory synapses by the parkin ubiquitin ligase
Mutations in the PARK2 gene cause hereditary Parkinson disease (PD). The PARK2 gene product, termed parkin, is an E3 ubiquitin ligase that mediates the transfer of ubiquitin onto diverse substrate proteins. Despite progress in defining the molecular properties and substrates of parkin, little is kno...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2614788/ https://ncbi.nlm.nih.gov/pubmed/19033459 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802280105 |
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