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The ubiquitin E3 ligase parkin regulates the proapoptotic function of Bax

Autosomal recessive loss-of-function mutations within the PARK2 gene functionally inactivate the E3 ubiquitin ligase parkin, resulting in neurodegeneration of catecholaminergic neurons and a familial form of Parkinson disease. Current evidence suggests both a mitochondrial function for parkin and a...

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Autors principals: Johnson, Bethann N., Berger, Alison K., Cortese, Giuseppe P., LaVoie, Matthew J.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341078/
https://ncbi.nlm.nih.gov/pubmed/22460798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1113248109
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