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The ubiquitin E3 ligase parkin regulates the proapoptotic function of Bax
Autosomal recessive loss-of-function mutations within the PARK2 gene functionally inactivate the E3 ubiquitin ligase parkin, resulting in neurodegeneration of catecholaminergic neurons and a familial form of Parkinson disease. Current evidence suggests both a mitochondrial function for parkin and a...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3341078/ https://ncbi.nlm.nih.gov/pubmed/22460798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1113248109 |
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