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Helper virus-mediated downregulation of transgene expression permits production of recalcitrant helper-dependent adenoviral vector
Helper-dependent adenoviral vectors (HDAd) that express certain transgene products are impossible to produce because the transgene product is toxic to the producer cells, especially when made in large amounts during vector production. Downregulating transgene expression from the HDAd during vector p...
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| Published in: | Mol Ther Methods Clin Dev |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4898405/ https://ncbi.nlm.nih.gov/pubmed/27331077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2016.39 |
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