SR-A and SREC-I Are Kupffer and Endothelial Cell Receptors for Helper-dependent Adenoviral Vectors

Helper-dependent adenoviral (HDAd) vectors can mediate long-term, high-level transgene expression from transduced hepatocytes with no chronic toxicity. However, a toxic acute response with potentially lethal consequences has hindered their clinical applications. Liver sinusoidal endothelial cells (L...

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Bibliographische Detailangaben
Hauptverfasser: Piccolo, Pasquale, Vetrini, Francesco, Mithbaokar, Pratibha, Grove, Nathan C, Bertin, Terry, Palmer, Donna, Ng, Philip, Brunetti-Pierri, Nicola
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2013
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616528/
https://ncbi.nlm.nih.gov/pubmed/23358188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.287
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