Nanoparticles coated with high molecular weight PEG penetrate mucus and provide uniform vaginal and colorectal distribution in vivo

AIM: We previously reported that nanoparticles (NPs) coated with 10 kDa PEG were mucoadhesive. Here, we demonstrate that by increasing the surface density, PEG with molecular weight (MW) as high as 40 kDa can be used as a mucoinert NP surface coating. MATERIALS & METHODS: We compared two sets of...

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Bibliografische gegevens
Gepubliceerd in:Nanomedicine (Lond)
Hoofdauteurs: Maisel, Katharina, Reddy, Mihika, Xu, Qingguo, Chattopadhyay, Sumon, Cone, Richard, Ensign, Laura M, Hanes, Justin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Future Medicine Ltd 2016
Onderwerpen:
Short Communication
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4897967/
https://ncbi.nlm.nih.gov/pubmed/27171816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/nnm-2016-0047
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