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Effect of surface chemistry on nanoparticle interaction with gastrointestinal mucus and distribution in the gastrointestinal tract following oral and rectal administration in the mouse

It is believed that mucoadhesive surface properties on particles delivered to the gastrointestinal (GI) tract improve oral absorption or local targeting of various difficult-to-deliver drug classes. To test the effect of nanoparticle mucoadhesion on distribution of nanoparticles in the GI tract, we...

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Publicat a:J Control Release
Autors principals: Maisel, Katharina, Ensign, Laura, Reddy, Mihika, Cone, Richard, Hanes, Justin
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4272879/
https://ncbi.nlm.nih.gov/pubmed/25449804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2014.10.026
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