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Effect of surface chemistry on nanoparticle interaction with gastrointestinal mucus and distribution in the gastrointestinal tract following oral and rectal administration in the mouse

It is believed that mucoadhesive surface properties on particles delivered to the gastrointestinal (GI) tract improve oral absorption or local targeting of various difficult-to-deliver drug classes. To test the effect of nanoparticle mucoadhesion on distribution of nanoparticles in the GI tract, we...

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Bibliografiske detaljer
Udgivet i:J Control Release
Main Authors: Maisel, Katharina, Ensign, Laura, Reddy, Mihika, Cone, Richard, Hanes, Justin
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4272879/
https://ncbi.nlm.nih.gov/pubmed/25449804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2014.10.026
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