Pretreatment of Human Cervicovaginal Mucus with Pluronic F127 Enhances Nanoparticle Penetration without Compromising Mucus Barrier Properties to Herpes Simplex Virus

[Image: see text] Mucosal drug delivery nanotechnologies are limited by the mucus barrier that protects nearly all epithelial surfaces not covered with skin. Most polymeric nanoparticles, including polystyrene nanoparticles (PS), strongly adhere to mucus, thereby limiting penetration and facilitatin...

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Библиографические подробности
Опубликовано в: :Biomacromolecules
Главные авторы: Ensign, Laura M., Lai, Samuel K., Wang, Ying-Ying, Yang, Ming, Mert, Olcay, Hanes, Justin, Cone, Richard
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2014
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4261994/
https://ncbi.nlm.nih.gov/pubmed/25347518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bm501419z
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