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Effect of surface chemistry on nanoparticle interaction with gastrointestinal mucus and distribution in the gastrointestinal tract following oral and rectal administration in the mouse

It is believed that mucoadhesive surface properties on particles delivered to the gastrointestinal (GI) tract improve oral absorption or local targeting of various difficult-to-deliver drug classes. To test the effect of nanoparticle mucoadhesion on distribution of nanoparticles in the GI tract, we...

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Bibliografske podrobnosti
izdano v:J Control Release
Main Authors: Maisel, Katharina, Ensign, Laura, Reddy, Mihika, Cone, Richard, Hanes, Justin
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4272879/
https://ncbi.nlm.nih.gov/pubmed/25449804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2014.10.026
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