Nanoparticles coated with high molecular weight PEG penetrate mucus and provide uniform vaginal and colorectal distribution in vivo

AIM: We previously reported that nanoparticles (NPs) coated with 10 kDa PEG were mucoadhesive. Here, we demonstrate that by increasing the surface density, PEG with molecular weight (MW) as high as 40 kDa can be used as a mucoinert NP surface coating. MATERIALS & METHODS: We compared two sets of...

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Publicado en:Nanomedicine (Lond)
Autores principales: Maisel, Katharina, Reddy, Mihika, Xu, Qingguo, Chattopadhyay, Sumon, Cone, Richard, Ensign, Laura M, Hanes, Justin
Formato: Artigo
Lenguaje:Inglês
Publicado: Future Medicine Ltd 2016
Materias:
Short Communication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4897967/
https://ncbi.nlm.nih.gov/pubmed/27171816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/nnm-2016-0047
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