Anilinoquinazoline inhibitors of the RET kinase domain—Elaboration of the 7-position

We have previously reported a series of anilinoquinazoline derivatives as potent and selective biochemical inhibitors of the RET kinase domain. However, these derivatives displayed diminished cellular potency. Herein we describe further optimisation of the series through modification of their physic...

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Publié dans:Bioorg Med Chem Lett
Auteurs principaux: Jordan, Allan M., Begum, Habiba, Fairweather, Emma, Fritzl, Samantha, Goldberg, Kristin, Hopkins, Gemma V., Hamilton, Niall M., Lyons, Amanda J., March, H. Nikki, Newton, Rebecca, Small, Helen F., Vishwanath, Swamy, Waddell, Ian D., Waszkowycz, Bohdan, Watson, Amanda J., Ogilvie, Donald J.
Format: Artigo
Langue:Inglês
Publié: Elsevier Science Ltd 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896930/
https://ncbi.nlm.nih.gov/pubmed/27086121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.03.100
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