Identification of selective inhibitors of RET and comparison with current clinical candidates through development and validation of a robust screening cascade [version 2; referees: 4 approved]

RET (REarranged during Transfection) is a receptor tyrosine kinase, which plays pivotal roles in regulating cell survival, differentiation, proliferation, migration and chemotaxis. Activation of RET is a mechanism of oncogenesis in medullary thyroid carcinomas where both germline and sporadic activa...

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Main Authors: Amanda J. Watson, Gemma V. Hopkins, Samantha Hitchin, Habiba Begum, Stuart Jones, Allan Jordan, Sarah Holt, H. Nikki March, Rebecca Newton, Helen Small, Alex Stowell, Ian D. Waddell, Bohdan Waszkowycz, Donald J. Ogilvie
Formato: Artigo
Idioma:Inglês
Publicado em: F1000 Research Ltd 2016-08-01
Colecção:F1000Research
Assuntos:
Methods for Diagnostic & Therapeutic Studies
Molecular Pharmacology
Acesso em linha:http://f1000research.com/articles/5-1005/v2
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