Anilinoquinazoline inhibitors of the RET kinase domain—Elaboration of the 7-position

We have previously reported a series of anilinoquinazoline derivatives as potent and selective biochemical inhibitors of the RET kinase domain. However, these derivatives displayed diminished cellular potency. Herein we describe further optimisation of the series through modification of their physic...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Jordan, Allan M., Begum, Habiba, Fairweather, Emma, Fritzl, Samantha, Goldberg, Kristin, Hopkins, Gemma V., Hamilton, Niall M., Lyons, Amanda J., March, H. Nikki, Newton, Rebecca, Small, Helen F., Vishwanath, Swamy, Waddell, Ian D., Waszkowycz, Bohdan, Watson, Amanda J., Ogilvie, Donald J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science Ltd 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896930/
https://ncbi.nlm.nih.gov/pubmed/27086121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.03.100
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