Anilinoquinazoline inhibitors of the RET kinase domain—Elaboration of the 7-position

We have previously reported a series of anilinoquinazoline derivatives as potent and selective biochemical inhibitors of the RET kinase domain. However, these derivatives displayed diminished cellular potency. Herein we describe further optimisation of the series through modification of their physic...

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Bibliografiset tiedot
Julkaisussa:Bioorg Med Chem Lett
Päätekijät: Jordan, Allan M., Begum, Habiba, Fairweather, Emma, Fritzl, Samantha, Goldberg, Kristin, Hopkins, Gemma V., Hamilton, Niall M., Lyons, Amanda J., March, H. Nikki, Newton, Rebecca, Small, Helen F., Vishwanath, Swamy, Waddell, Ian D., Waszkowycz, Bohdan, Watson, Amanda J., Ogilvie, Donald J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Elsevier Science Ltd 2016
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896930/
https://ncbi.nlm.nih.gov/pubmed/27086121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.03.100
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