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Identification of selective inhibitors of RET and comparison with current clinical candidates through development and validation of a robust screening cascade
RET (REarranged during Transfection) is a receptor tyrosine kinase, which plays pivotal roles in regulating cell survival, differentiation, proliferation, migration and chemotaxis. Activation of RET is a mechanism of oncogenesis in medullary thyroid carcinomas where both germline and sporadic activa...
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| Pubblicato in: | F1000Res |
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| Autori principali: | , , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
F1000Research
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4937820/ https://ncbi.nlm.nih.gov/pubmed/27429741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/f1000research.8724.2 |
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