Broadly neutralizing epitopes in the Plasmodium vivax vaccine candidate Duffy Binding Protein

Plasmodium vivax Duffy Binding Protein (PvDBP) is the most promising vaccine candidate for P. vivax malaria. The polymorphic nature of PvDBP induces strain-specific immune responses, however, and the epitopes of broadly neutralizing antibodies are unknown. These features hamper the rational design o...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Chen, Edwin, Salinas, Nichole D., Huang, Yining, Ntumngia, Francis, Plasencia, Manolo D., Gross, Michael L., Adams, John H., Tolia, Niraj Harish
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896725/
https://ncbi.nlm.nih.gov/pubmed/27194724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600488113
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