Leukotriene E(4) elicits respiratory epithelial cell mucin release through the G-protein–coupled receptor, GPR99

Cysteinyl leukotrienes (cysLTs), leukotriene C(4) (LTC(4)), LTD(4), and LTE(4) are proinflammatory lipid mediators with pathobiologic function in asthma. LTE(4), the stable cysLT, is a weak agonist for the type 1 and type 2 cysLT receptors (CysLTRs), which constrict airway smooth muscle, but elicits...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Bankova, Lora G., Lai, Juying, Yoshimoto, Eri, Boyce, Joshua A., Austen, K. Frank, Kanaoka, Yoshihide, Barrett, Nora A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896673/
https://ncbi.nlm.nih.gov/pubmed/27185938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1605957113
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