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Leukotriene E(4) elicits respiratory epithelial cell mucin release through the G-protein–coupled receptor, GPR99
Cysteinyl leukotrienes (cysLTs), leukotriene C(4) (LTC(4)), LTD(4), and LTE(4) are proinflammatory lipid mediators with pathobiologic function in asthma. LTE(4), the stable cysLT, is a weak agonist for the type 1 and type 2 cysLT receptors (CysLTRs), which constrict airway smooth muscle, but elicits...
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| Izdano u: | Proc Natl Acad Sci U S A |
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| Glavni autori: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2016
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4896673/ https://ncbi.nlm.nih.gov/pubmed/27185938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1605957113 |
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