Target interaction profiling of midostaurin and its metabolites in neoplastic mast cells predicts distinct effects on activation and growth

Proteomic-based drug testing is an emerging approach to establish the clinical value and anti-neoplastic potential of multi-kinase inhibitors. The multikinase inhibitor midostaurin (PKC412) is a promising new agent used to treat patients with advanced systemic mastocytosis (SM). We examined the targ...

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Publicado no:Leukemia
Main Authors: Peter, Barbara, Winter, Georg E., Blatt, Katharina, Bennett, Keiryn L., Stefanzl, Gabriele, Rix, Uwe, Eisenwort, Gregor, Hadzijusufovic, Emir, Gridling, Manuela, Dutreix, Catherine, Hoermann, Gregor, Schwaab, Juliana, Radia, Deepti, Roesel, Johannes, Manley, Paul W., Reiter, Andreas, Superti-Furga, Giulio, Valent, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896384/
https://ncbi.nlm.nih.gov/pubmed/26349526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2015.242
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