The KIT and PDGFRA switch-control inhibitor DCC-2618 blocks growth and survival of multiple neoplastic cell types in advanced mastocytosis

Systemic mastocytosis is a complex disease defined by abnormal growth and accumulation of neoplastic mast cells in various organs. Most patients exhibit a D816V-mutated variant of KIT, which confers resistance against imatinib. Clinical problems in systemic mastocytosis arise from mediator-related s...

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Publicat a:Haematologica
Autors principals: Schneeweiss, Mathias, Peter, Barbara, Bibi, Siham, Eisenwort, Gregor, Smiljkovic, Dubravka, Blatt, Katharina, Jawhar, Mohamad, Berger, Daniela, Stefanzl, Gabriele, Herndlhofer, Susanne, Greiner, Georg, Hoermann, Gregor, Hadzijusufovic, Emir, Gleixner, Karoline V., Bettelheim, Peter, Geissler, Klaus, Sperr, Wolfgang R., Reiter, Andreas, Arock, Michel, Valent, Peter
Format: Artigo
Idioma:Inglês
Publicat: Ferrata Storti Foundation 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927976/
https://ncbi.nlm.nih.gov/pubmed/29439183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2017.179895
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