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Penetrance of Congenital Heart Disease in a Mouse Model of Down Syndrome Depends on a Trisomic Potentiator of a Disomic Modifier

Down syndrome (DS) is a significant risk factor for congenital heart disease (CHD), increasing the incidence 50 times over the general population. However, half of people with DS have a normal heart and thus trisomy 21 is not sufficient to cause CHD by itself. Ts65Dn mice are trisomic for orthologs...

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Bibliografske podrobnosti
izdano v:Genetics
Main Authors: Li, Huiqing, Edie, Sarah, Klinedinst, Donna, Jeong, Jun Seop, Blackshaw, Seth, Maslen, Cheryl L., Reeves, Roger H.
Format: Artigo
Jezik:Inglês
Izdano: Genetics Society of America 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896192/
https://ncbi.nlm.nih.gov/pubmed/27029737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.116.188045
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