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Trisomy 21-associated increases in chromosomal instability are unmasked by comparing isogenic trisomic/disomic leukocytes from people with mosaic Down syndrome

Down syndrome, which results from a trisomic imbalance for chromosome 21, has been associated with 80+ phenotypic traits. However, the cellular changes that arise in somatic cells due to this aneuploid condition are not fully understood. The primary aim of this study was to determine if germline tri...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Rafferty, Kelly, Archer, Kellie J., Turner, Kristi, Brown, Ruth, Jackson-Cook, Colleen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2021
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8291705/
https://ncbi.nlm.nih.gov/pubmed/34283872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0254806
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