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Complex Contributions of Ets2 to Craniofacial and Thymus Phenotypes of Trisomic “Down Syndrome” Mice
Ts65Dn mice have segmental trisomy for orthologs of about half of the genes on human chromosome 21, including Ets2. These mice develop anomalies of the cranial skeleton and thymus that parallel those in Down syndrome. Over-expression of the Ets2 transcription factor gene was posited to be sufficient...
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| Hoofdauteurs: | , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2009
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2903219/ https://ncbi.nlm.nih.gov/pubmed/19764029 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajmg.a.33012 |
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