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Safety and tolerability of an anti-CD19 monoclonal antibody, MEDI-551, in subjects with systemic sclerosis: a phase I, randomized, placebo-controlled, escalating single-dose study
BACKGROUND: Systemic sclerosis (SSc) is a clinically heterogeneous, life-threatening disease characterized by fibrosis, microvasculopathy, and autoimmunity. Extensive nonclinical and clinical data implicate B cells in the pathogenesis of SSc. MEDI-551 is an investigational humanized monoclonal antib...
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發表在: | Arthritis Res Ther |
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Main Authors: | , , , , , , , , , , , , , , |
格式: | Artigo |
語言: | Inglês |
出版: |
BioMed Central
2016
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主題: | |
在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4895815/ https://ncbi.nlm.nih.gov/pubmed/27267753 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-016-1021-2 |
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