Single Dose of Glycoengineered Anti-CD19 Antibody (MEDI551) Disrupts Experimental Autoimmune Encephalomyelitis by Inhibiting Pathogenic Adaptive Immune Responses in the Bone Marrow and Spinal Cord while Preserving Peripheral Regulatory Mechanisms()

Plasma cells and the autoreactive Abs they produce are suspected to contribute to the pathogenesis of multiple sclerosis, but recent attempts to target these components of humoral immunity have failed. MEDI551, an anti-CD19 Ab that depletes mature B cells including plasma cells may offer a compellin...

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Bibliographic Details
Published in:J Immunol
Main Authors: Chen, Ding, Blazek, Monica, Ireland, Sara, Ortega, Sterling, Kong, Xiangmei, Meeuwissen, Anouk, Stowe, Ann, Carter, Laura, Wang, Yue, Herbst, Ronald, Monson, Nancy L.
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4373313/
https://ncbi.nlm.nih.gov/pubmed/25281717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401478
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