Single Dose of Glycoengineered Anti-CD19 Antibody (MEDI551) Disrupts Experimental Autoimmune Encephalomyelitis by Inhibiting Pathogenic Adaptive Immune Responses in the Bone Marrow and Spinal Cord while Preserving Peripheral Regulatory Mechanisms()

Plasma cells and the autoreactive Abs they produce are suspected to contribute to the pathogenesis of multiple sclerosis, but recent attempts to target these components of humoral immunity have failed. MEDI551, an anti-CD19 Ab that depletes mature B cells including plasma cells may offer a compellin...

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Veröffentlicht in:J Immunol
Hauptverfasser: Chen, Ding, Blazek, Monica, Ireland, Sara, Ortega, Sterling, Kong, Xiangmei, Meeuwissen, Anouk, Stowe, Ann, Carter, Laura, Wang, Yue, Herbst, Ronald, Monson, Nancy L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4373313/
https://ncbi.nlm.nih.gov/pubmed/25281717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401478
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